A unique glimpse into the crosstalk between different epigenetic mechanisms in porcine embryonic development(dagger)
文献类型： 外文期刊
作者： Gan, Jianyu 1 ; Zhang, Xin 1 ; Lu, Yongchang 1 ; Wu, Zhenfang 1 ; Cai, Gengyuan 1 ; Hong, Linjun 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Natl Engn Res Ctr Breeding Swine Ind, Guangzhou, Peoples R China
2.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, Guangzhou, Peoples R China
3.State Key Lab Conservat & Utilizat Subtrop Agrobi, Guangzhou, Peoples R China
关键词： pig; embryo; DNA methylation; histone modification; non-coding RNA; chromatin accessibility
期刊名称：BIOLOGY OF REPRODUCTION （ 影响因子：4.161； 五年影响因子：4.522 ）
ISSN： 0006-3363
年卷期：
页码：
收录情况： SCI
摘要： In this review, four epigenetic modifications (DNA methylation, histone modification, non-coding RNA function, and chromatin accessibility) were described in porcine embryonic development, and the possible crosstalk between them was explored in order to provide references for further understanding and studying the role of epigenetic modification in embryonic development. The pig is an excellent animal model for simulating human physiology and a major animal for meat production and xenotransplantation. Therefore, researching porcine embryonic development is crucial for studying human reproductive diseases and improving litter size in commercial pigs. Embryonic development in pigs occurs under a complex regulatory mechanism, in which epigenetic regulatory mechanisms play an essential role. Recently, studies on the effects of epigenetic modifications on embryonic development have been conducted at different developmental stages and in different cell lines. Increasing evidence suggests that a certain amount of crosstalk exists between different epigenetic modifications. This review describes four regulatory mechanisms of epigenetics involved in porcine embryonic development: DNA methylation, histone modification, non-coding RNA function, and chromatin accessibility, and explores the possible crosstalk between them.
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