Prostaglandin E2 promotes Staphylococcus aureus infection via EP4 receptor in bovine endometrium
文献类型： 外文期刊
作者： Liu, Kun 1 ; Mao, Wei 1 ; Liu, Bo 1 ; Li, Tingting 1 ; Wang, Xinfei 1 ; Pei, Le 4 ; Cao, Jinshan 1 ; Wang, Fenglong 3 ;
作者机构： 1.Inner Mongolia Agr Univ, Coll Vet Med, Lab Vet Pharmacol, 306 Zhaowuda Rd, Saihan Dist 010018, Hohhot, Peoples R China
2.Minist Agr, Key Lab Clin Diag & Treatment Tech Anima Dis, Hohhot, Peoples R China
3.Inner Mongolia Agr Univ, Coll Vet Med, Lab Vet Pathol, 306 Zhaowuda Rd, Saihan Dist 010018, Hohhot, Peoples R China
4.Inner Mongolia Acad Agr & Anim Husb Sci, Vet Res Inst, Hohhot, Peoples R China
关键词： Bovine endometritis; Prostaglandin E2; S; aureus; Infection; EP4 receptor
期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.664 ）
ISSN： 0882-4010
年卷期： 2021 年 158 卷
页码：
收录情况： SCI
摘要： Prostaglandin E2 (PGE2) enhances Staphylococcus aureus infection but its mechanism is not well understood. Here, we examined the effect of PGE2 on Staphylococcal Protein A (SPA) expression in bovine endometrium and determined the role of select PGE2 receptors (i.e., EP2 and EP4) in adhesion and internalization of S. aureus. S. aureus isolate SA113 was used for in vitro infection of bovine endometrial tissues and epithelial cells, with treatment conditions consisting of untreated control, SA113 treatment, SA113 + PGE2, SA113 + PGE2 + EP2 receptor antagonist (AH-6809), and SA113 + PGE2 + EP4 receptor antagonist (AH-23848). Immunofluorescence assay revealed that PGE2 could promote SPA expression in S. aureus-infected bovine endometrial tissues. PGE2 also enhanced the adhesion and internalization of S. aureus in bovine endometrial cells. The addition of EP4 antagonist, but not the EP2 antagonist, abrogated the ability of PGE2 to promote S. aureus SPA expression, adhesion, and internalization in endometrial cells. Our findings suggest that S. aureus infection in the endometrium is enhanced by PGE2 through the EP4 receptor. This result is essential for the development of new approach to treating S. aureus infection, such as the application of EP4 antagonist as an adjunct drug treatment.
- 相关文献
作者其他论文 更多>>
-
The effect of taurochenodeoxycholic acid on the glucocorticoid receptor-mediated PLC-IP3-calcium pathway in synoviocytes derived from a rat adjuvant arthritis model
作者：Guanqia, Sangjide;Li, Peifeng;Cao, Jinshan;Mao, Wei;Wu, Jindi;Guanqia, Sangjide;Li, Peifeng;Cao, Jinshan;Bai, Fan;Qian, Yinghong;Mao, Wei
关键词：taurochenodeoxycholic acid; rat adjuvant arthritis model; glucocorticoid receptor; phospholipase C-inositol trisphosphate-Ca2+ signalling pathway
-
Prostaglandin E2 accumulation is closely associated with S. aureus-infected bovine endometritis
作者：Liu, Kun;Shen, Yuan;Zhang, Nan;Liu, Kun;Shen, Yuan;Wu, Jindi;Mao, Wei;Cao, Jinshan;Pei, Le;Qian, Yinghong
关键词：Endometritis; S. aureus infection; Prostaglandin E2; Immunology
-
A Single-Cell Atlas of an Early Mongolian Sheep Embryo
作者：He, Tingyi;Guo, Wenrui;Su, Hong;Dou, Aolei;Chen, Lu;Ma, Teng;Liu, Moning;Su, Budeng;Qi, Wangmei;Li, Haijun;Mao, Wei;Wang, Xiumei;Cao, Guifang;He, Tingyi;Yang, Yanyan;Yang, Guang;Li, Xihe;Song, Yongli;Yang, Guang;Li, Xihe;Song, Yongli;Su, Jie
关键词：Mongolian sheep; embryo; scRNA-seq; Hippo signaling pathway
-
Equine ß-defensin 1 regulates cytokine expression and phagocytosis in S. aureus-infected mouse monocyte macrophages via the Paxillin-FAK-PI3K pathway
作者：Pei, Le;Hou, Yongyue;Feng, Ying;Li, Feng;Zhang, Yuemei;Song, Yue;Pei, Le;Su, Hong;Cao, Guifang;Liu, Kun
关键词：Equine ss-defensin 1; S. aureus infection; Macrophage Paxillin-FAK-PI3K pathway
-
Staphylococcus aureus increases Prostaglandin E-2 secretion in cow neutrophils by activating TLR2, TLR4, and NLRP3 inflammasome signaling pathways
作者：Zhang, Kai;Jia, Yan;Jiang, Xueying;Zhang, Shuangyi;Liu, Bo;Cao, Jinshan;Mao, Wei;Zhang, Kai;Jia, Yan;Jiang, Xueying;Zhang, Shuangyi;Liu, Bo;Cao, Jinshan;Mao, Wei;Qian, Yinghong;Song, Yongli
关键词：Staphylococcus aureus; Prostaglandin E-2; neutrophils; toll-like receptor 2; toll-like receptor 4; NLR pyrin domain-containing 3
-
Equus beta-Defensin-1 Regulates Innate IMMUNE Response in S. aureus-Infected Mouse Monocyte Macrophage
作者：Pei, Le;Wei, Wei;Su, Hong;Cao, Guifang;Pei, Le;Li, Feng;Feng, Ying;Wang, Daqing;Li, Xiunan;Hou, Yongyue;Liu, Kun
关键词：beta-defensin-1; Equus; S. aureus-infected; immune response
-
Anti-inflammatory effects of the prostaglandin D-2/prostaglandin DP1 receptor and lipocalin-type prostaglandin D-2 synthase/prostaglandin D-2 pathways in bacteria-induced bovine endometrial tissue
作者：Wu, Jindi;Borjigin, Gerelt;Wu, Jindi;Mao, Wei;Liu, Bo;Yang, Xiaolin;Zhang, Jing;Li, Tingting;Cao, Jinshan;Wu, Jindi;Mao, Wei;Liu, Bo;Yang, Xiaolin;Zhang, Jing;Li, Tingting;Cao, Jinshan;Bai, Fan
关键词：DP1 receptor; Escherichia coli; Staphylococcus aureus; anti-inflammatory effects; bovine endometrial tissue; L-PGDS; PGD(2) pathway
