Antibacterial Indole-Diterpenoid Alkaloids from the Marine Fungus Penicillium sp. ZYX-Z-718
文献类型： 外文期刊
作者： Yang, Li 1 ; Quan, Miao-Miao 3 ; Ma, Qing-Yun 1 ; Xie, Qing-Yi 1 ; Gai, Cui-Juan 1 ; Dai, Hao-Fu 1 ; Hao, Yu. -E. 3 ; Zhao, You-Xing 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Haikou Key Lab Res & Utilizat Trop Nat Prod, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China
2.Chinese Acad Trop Agr Sci, Natl Key Lab Trop Crop Breeding, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China
3.Univ South China, Heng Yang Med Sch, Dept Publ Hlth Lab Sci, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China
4.Second Peoples Hosp Shaoyang, Shaoyang 422000, Hunan, Peoples R China
关键词： Penicillium sp.; Marine fungus; Indole-diterpenoid; Antibacterial activity
期刊名称：CHEMISTRY & BIODIVERSITY （ 影响因子：2.5； 五年影响因子：2.6 ）
ISSN： 1612-1872
年卷期： 2024 年 21 卷 12 期
页码：
收录情况： SCI
摘要： Two new indole-diterpenoids, penpaxilloids F and G (1 and 2), along with 11 known analogues (3-13), were isolated from the marine fungus Penicillium sp. ZYX-Z-718. The structures of the new compounds were identified by extensive spectroscopic analyses including HR-ESI-MS, UV, and NMR, as well as theoretical NMR chemical shifts and ECD calculations. Compounds 6 and 10 showed antibacterial activity against Gram-positive bacteria including Staphylococcus aureus, Bacillus subtilis, and MRSA with MIC values ranging from 16.0-32.0 mu g/mL.
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