Humulane-Type Macrocyclic Sesquiterpenoids From the Endophytic Fungus Penicillium sp. of Carica papaya
文献类型： 外文期刊
作者： Wang, Fu-Run 1 ; Yang, Li 1 ; Kong, Fan-Dong 4 ; Ma, Qing-Yun 1 ; Xie, Qing-Yi 1 ; Wu, You-Gen 2 ; Dai, Hao-Fu 5 ; Chen, Ping 2 ; Xiao, Na 3 ; Zhao, You-Xing 1 ;
作者机构： 1.CATAS, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou, Hainan, Peoples R China
2.Hainan Univ, Coll Hort, Key Lab Qual Regulat Trop Hort Crops Hainan Prov, Haikou, Hainan, Peoples R China
3.Shandong Agr Univ, Coll Agron, State Key Lab Crop Biol, Tai An, Shandong, Peoples R China
4.Guangxi Univ Nationalities, Guangxi Collaborat Innovat Ctr Chem & Engn Forest, Guangxi Key Lab Chem & Engn Forest Prod,Key Lab C, State Ethn Affairs Commiss,Sch Chem & Chem Engn, Nanning, Peoples R China
5.CATAS, Hainan Inst Trop Agr Resources, Haikou, Hainan, Peoples R China
关键词： endophytic fungus; Penicillium sp; humulane-type sesquiterpenoid; anti-diabetic activity; cAMP accumulation
期刊名称：FRONTIERS IN CHEMISTRY （ 影响因子：5.545； 五年影响因子：5.869 ）
ISSN： 2296-2646
年卷期： 2021 年 9 卷
页码：
收录情况： SCI
摘要： Three new humulane-type sesquiterpenoids, penirolide A (1), penirolide B (2), and 10-acetyl-phomanoxide (3), together with three known compounds aurasperone A (4), pughiinin A (5), and cyclo(l-Leu-l-Phe) (6) were isolated from the endophytic fungus Penicillium sp. derived from the leaves of Carica papaya L. Their structures including their absolute configurations were determined based on the analysis of NMR and HRESIMS spectra, NMR chemical shifts, and ECD calculations. Compounds 2, 3, 5, and 6 significantly inhibited glucagon-induced hepatic glucose production, with EC50 values of 33.3, 36.1, 18.8, and 32.1 mu M, respectively. Further study revealed that compounds 2, 3, 5, and 6 inhibited hepatic glucose production by suppression of glucagon-induced cAMP accumulation.
- 相关文献
作者其他论文 更多>>
-
New Isocoumarins from an Endophytic Fungal Strain Diaporthe arengae M2 and their Antibacterial Activities
作者：Liu, De-Sui;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Liu, De-Sui;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Liu, De-Sui;Zhang, Jun-Feng;Wu, You-Gen
关键词：Endophytic fungi;
Diaporthe sp.; Isocoumarin derivatives; Antibacterial activity -
2-(2-Phenylethyl)chromone-Sesquiterpene Hybrids from Agarwood of Aquilaria sinensis: Characterization and Biological Activity Evaluation
作者：Xu, Guan-Hua;Liu, Shou-Bai;Xu, Guan-Hua;Wang, Ya-Li;Wang, Hao;Chen, Hui-Qin;Dong, Wen-Hua;Huang, Sheng-Zhuo;Cai, Cai-Hong;Yuan, Jing-Zhe;Mei, Wen-Li;Dai, Hao-Fu
关键词：Hainan agarwood; 2-(2-phenylethyl)chromone-sesquiterpene hybrids; structure elucidation; anti-inflammatory activity; neuroprotective activity; cytotoxic activity
-
Three new dimeric 2-(2-phenethyl)chromones from the agarwood of Aquilaria malaccensis
作者：Yan, Xian-Yun;Liang, Lin-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu
关键词：Agarwood; Aquilaria malaccensis; 2-(2-phenethyl)chromone dimers; Anti-inflammatory activity
-
Discovery of ganodecalone A, from Ganoderma calidophilum for the treatment of acute gastric ulcers by binding to ALOX5 via the MAPK/ NF-κB/iNOS signaling
作者：Liu, Yu;Li, Weikang;Tong, Zhao;Luo, Duqiang;Liu, Yu;Li, Weikang;Tong, Zhao;Luo, Duqiang;Yang, Li;Zhao, Youxing;Wang, Zhen
关键词：Gastric ulcer; Ganoderma calidophilum; Ganodecalone A; Oxidative stress; Inflammation; MAPK/NF-kappa B/iNOS signalling
-
Nauclofficines A and B, two novel monoterpenoid indole alkaloids from the Li folk herb Nauclea officinalis with anti-allergic inflammatory effects on RBL-2H3 cells
作者：Li, Yan-li;Wang, Ting;Wang, Hao;Wang, Qi;Cai, Cai-Hong;Mei, Wen-Li;Dai, Hao-Fu;Huang, Sheng-Zhuo;Dai, Hao-Fu;Huang, Sheng-Zhuo;Li, Yan-li;Xu, Feng-Qing;Wang, Ting;Zhu, Guo-Peng
关键词：Nauclea officinalis; Monoterpenoid indole alkaloid; Li folk medicine; Anti-inflammatory activity; Nauclofficine
-
Two unprecedented 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones with anti-Helicobacter pylori activity from agarwood of Aquilaria sinensis 'Reke 1'
作者：Qin, Ke-Xin;Jian, Jie;Qin, Ke-Xin;Wang, Hao;Yang, Li;Wei, Yan-Mei;Cai, Cai-Hong;Chen, Hui-Qin;Dong, Wen-Hua;Li, Wei;Yan, Xian-Yun;Zeng, Jun;Mei, Wen-Li;Dai, Haofu;Qin, Ke-Xin;Wang, Hao;Yang, Li;Wei, Yan-Mei;Cai, Cai-Hong;Chen, Hui-Qin;Dong, Wen-Hua;Li, Wei;Yan, Xian-Yun;Zeng, Jun;Mei, Wen-Li;Dai, Haofu
关键词：Agarwood; Aquilaria sinensis 'Reke 1 '; 2-(2-Phenylethyl)chromone; Anti -Helicobacter pylori activity
-
Formation of N-Hydroxyethylisoindolinone Derivatives in Fungi Requires Highly Coordinated Consecutive Oxidation Steps
作者：Li, Zhang-Hai;Dai, Yu;Li, Shu-Ming;Zhou, Jing;Yang, Li;Yang, Li
关键词：
