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Humulane-Type Macrocyclic Sesquiterpenoids From the Endophytic Fungus Penicillium sp. of Carica papaya

文献类型： 外文期刊

作者： Wang, Fu-Run 1 ; Yang, Li 1 ; Kong, Fan-Dong 4 ; Ma, Qing-Yun 1 ; Xie, Qing-Yi 1 ; Wu, You-Gen 2 ; Dai, Hao-Fu 5 ; Chen, Ping 2 ; Xiao, Na 3 ; Zhao, You-Xing 1 ;

作者机构： 1.CATAS, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou, Hainan, Peoples R China

2.Hainan Univ, Coll Hort, Key Lab Qual Regulat Trop Hort Crops Hainan Prov, Haikou, Hainan, Peoples R China

3.Shandong Agr Univ, Coll Agron, State Key Lab Crop Biol, Tai An, Shandong, Peoples R China

4.Guangxi Univ Nationalities, Guangxi Collaborat Innovat Ctr Chem & Engn Forest, Guangxi Key Lab Chem & Engn Forest Prod,Key Lab C, State Ethn Affairs Commiss,Sch Chem & Chem Engn, Nanning, Peoples R China

5.CATAS, Hainan Inst Trop Agr Resources, Haikou, Hainan, Peoples R China

关键词： endophytic fungus; Penicillium sp; humulane-type sesquiterpenoid; anti-diabetic activity; cAMP accumulation

期刊名称：FRONTIERS IN CHEMISTRY （ 影响因子：5.545； 五年影响因子：5.869 ）

ISSN： 2296-2646

年卷期： 2021 年 9 卷

页码：

收录情况： SCI

摘要： Three new humulane-type sesquiterpenoids, penirolide A (1), penirolide B (2), and 10-acetyl-phomanoxide (3), together with three known compounds aurasperone A (4), pughiinin A (5), and cyclo(l-Leu-l-Phe) (6) were isolated from the endophytic fungus Penicillium sp. derived from the leaves of Carica papaya L. Their structures including their absolute configurations were determined based on the analysis of NMR and HRESIMS spectra, NMR chemical shifts, and ECD calculations. Compounds 2, 3, 5, and 6 significantly inhibited glucagon-induced hepatic glucose production, with EC50 values of 33.3, 36.1, 18.8, and 32.1 mu M, respectively. Further study revealed that compounds 2, 3, 5, and 6 inhibited hepatic glucose production by suppression of glucagon-induced cAMP accumulation.

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