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Three New Quinazoline-Containing Indole Alkaloids From the Marine-Derived Fungus Aspergillus sp. HNMF114

文献类型： 外文期刊

作者： Liu, Sha-Sha 1 ; Yang, Li 2 ; Kong, Fan-Dong 3 ; Zhao, Jia-Hui 4 ; Yao, Li 4 ; Yuchi, Zhi-Guang 4 ; Ma, Qing-Yun 2 ; Xie, 1 ;

作者机构： 1.Hebei Univ, Coll Life Sci, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding, Peoples R China

2.CATAS, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou, Hainan, Peoples R China

3.Guangxi Univ Nat, Sch Chem & Chem Engn,State Ethn Affairs Commiss, Guangxi Collaborat Innovat Ctr Chem & Engn Forest, Guangxi Key Lab Chem & Engn Forest Prod,key Lab C, Nanning, Peoples R China

4.Tianjin Univ, Sch Pharmaceut Sci & Technol, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin Key Lab Modern Drug Delivery & HighEffici, Tianjin, Peoples R China

5.CATAS, Hainan Inst Trop Agr Resources, Haikou, Hainan, Peoples R China

关键词： marine-derived fungus; Aspergillus sp.; indole alkaloids; alpha-glucosidase inhibitory activity; ryanodine receptor

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：5.64； 五年影响因子：6.32 ）

ISSN： 1664-302X

年卷期： 2021 年 12 卷

页码：

收录情况： SCI

摘要： By feeding tryptophan to the marine-derived fungus Aspergillus sp. HNMF114 from the bivalve mollusk Sanguinolaria chinensis, 3 new quinazoline-containing indole alkaloids, named aspertoryadins H-J (1-3), along with 16 known ones (4-19), were obtained. The structures of the new compounds were elucidated by the analysis of spectroscopic data combined with quantum chemical calculations of nuclear magnetic resonance (NMR) chemical shifts and electron capture detector (ECD) spectra. Structurally, compound 3 represents the first example of this type of compound, bearing an amide group at C-3. Compounds 10 and 16 showed potent alpha-glucosidase inhibitory activity with IC50 values of 7.18 and 5.29 mu M, and compounds 13 and 14 showed a clear activation effect on the ryanodine receptor from Spodoptera frugiperda (sfRyR), which reduced the [Ca2+](ER) by 37.1 and 36.2%, respectively.

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