Cochliomycin H, a new 12-membered resorcylic acid lactone from sponge-derived fungus Curvularia sp. ZYX-Z-4
文献类型： 外文期刊
作者： Zhou, Jiu-Jiu 1 ; Yang, Li 2 ; Ma, Qing-Yun 2 ; Xie, Qing-Yi 2 ; Dai, Hao-Fu 2 ; Liu, You-Hua 1 ; Zhao, You-Xing 2 ;
作者机构： 1.Zhejiang Guangsha Vocat & Tech Univ Construct, Dongyang, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou, Hainan, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou, Hainan, Peoples R China
关键词：
Sponge;
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：1.6； 五年影响因子：2.0 ）
ISSN： 1478-6419
年卷期： 2024 年
页码：
收录情况： SCI
摘要： A new 12-membered resorcylic acid lactone, cochliomycin H (1), and one known resorcylic acid lactone, O-demethylated-zeaenol (2), were isolated from sponge-derived fungus Curvularia sp. ZYX-Z-4. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic as well as HR-ESI-MS analysis. The configuration of 1 was established by the NMR chemical shifts calculation followed by DP4+ analysis and ECD calculation. Compounds 1 and 2 were evaluated for the antifungal and neuroprotective activities and compound 2 showed comparable neuroprotective effect on the H2O2 injured SH-SY5Y cells to that of trolox.
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