文献类型： 外文期刊
作者： Dai, Lu-Ting 1 ; Yang, Li 1 ; Wang, Zi-Peng 1 ; Guo, Jiao-Cen 1 ; Ma, Qing-Yun 1 ; Xie, Qing-Yi 1 ; Dai, Hao-Fu 1 ; Yu, Zhi-Fang 3 ; Zhao, You-Xing 1 ;
作者机构： 1.Chinese Acad Trop Agr Sci, Haikou Key Lab Res & Utilizat Trop Nat Prod, Inst Trop Biosci & Biotechnol, Haikou, Peoples R China
2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Natl Key Lab Trop Crop Breeding, Haikou, Peoples R China
3.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing, Peoples R China
关键词： Penicillium sp.; steroid; PTP1B; anti-inflammatory; cytotoxicity; antibacterial activity
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：1.6； 五年影响因子：2.0 ）
ISSN： 1478-6419
年卷期： 2024 年
页码：
收录情况： SCI
摘要： A new steroid named persteroid (1) and seven known compounds (2-8) were isolated from the marine-derived fungus Penicillium sp. ZYX-Z-143. The structure of 1 was determined by HRESIMS, NMR, and ECD calculations. Compound 1 showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC50 value of 46.31 +/- 0.52 mu M. Moreover, compound 1 potently suppressed nitric oxide (NO) production on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The cytotoxicity and antibacterial activity of all isolates were tested. [GRAPHICS]
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