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Triterpenoids and meroterpenoids with alpha-glucosidase inhibitory activities from the fruiting bodies of Ganoderma australe

文献类型： 外文期刊

作者： Guo, Jiao-Cen 1 ; Yang, Li 1 ; Ma, Qing-Yun 1 ; Ge, Ya-Zhe 1 ; Kong, Fan-Dong 3 ; Zhou, Li-Man 3 ; Zhang, Fei 1 ; Xie, Qing-Yi 1 ; Yu, Zhi-Fang 2 ; Dai, Hao-Fu 4 ; Zhao, You-Xing 1 ;

作者机构： 1.CATAS, Haikou Key Lab Res & Utilizat Trop Nat Prod, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China

2.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China

3.Guangxi Univ Nationalities, Guangxi Collaborat Innovat Ctr Chem & Engn Forest, Sch Chem & Chem Engn,Guangxi Key Lab Chem & Engn, Key Lab Chem & Engn Forest Prod,State Ethn Affair, Nanning 530006, Peoples R China

4.CATAS, Hainan Acad Trop Agr Resource, Haikou 571101, Hainan, Peoples R China

关键词： Ganoderma australe; Triterpenoids; Meroterpenoids; alpha-glucosidase inhibitory activity

期刊名称：BIOORGANIC CHEMISTRY （ 影响因子：5.307； 五年影响因子：5.321 ）

ISSN： 0045-2068

年卷期： 2021 年 117 卷

页码：

收录情况： SCI

摘要： Macrofungi Ganoderma is a valuable medicinal fungus resource for human health and longevity in China. In this study, ten undescribed compounds including seven lostane-type triterpenoids, ganodaustralic acids A similar to G (1-7), one pair of meroterpenoid enantiomers, (-)-6'-O-ethyllingzhiol (8) and (+)-6'-O-ethyllingzhiol (9), and one polyhydroxylated sterol, 3-O-acetyl-fomentarol C (10), together with eight known compounds (11-18), were isolated from the fruiting bodies of Ganoderma australe. The structures of the new compounds were elucidated by extensive spectroscopic analysis as well as NMR and electronic circular dichroism (ECD) calculations. Compounds 4, 8, 9, and 12 showed significant a-glucosidase inhibitory activities with IC50 values in the range of 4.1-11.7 mu M, which were superior to that of positive control acarbose (213 mu M). Only compound 7 exhibited weak cytotoxicity against SGC-7901 cells.

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