Effects of Selenylation Modification on Immune-Enhancing Activity of Garlic Polysaccharide
文献类型： 外文期刊
作者： Qiu, Shulei 1 ; Chen, Jin 2 ; Qin, Tao 1 ; Hu, Yuanliang 1 ; Wang, Deyun 1 ; Fan, Qiang 3 ; Zhang, Cunshuai 4 ; Chen, Xin 1 ;
作者机构： 1.Nanjing Agr Univ, Coll Vet Med, Inst Tradit Chinese Vet Med, Nanjing, Jiangsu, Peoples R China
2.Jiangsu Acad Agr Sci, Natl Res Ctr Vet Biol Engn & Technol, Nanjing, Jiangsu, Peoples R China
3.China Inst Vet Drug Control, Beijing, Peoples R China
4.China Inst
期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）
ISSN： 1932-6203
年卷期： 2014 年 9 卷 1 期
页码：
收录情况： SCI
摘要： The garlic polysaccharide was modified by HNO3-Na2SeO3 method according to orthogonal design L-9(3(4)) to obtain nine selenizing garlic polysaccharides, sGPS(1)-sGPS(9). Their effects on chicken peripheral lymphocytes proliferation in vitro were compared by MTT assay. The results showed that sGPSs could significantly promote lymphocytes proliferation, sGPS(3), sGPS(5) and sGPS(6) presented stronger efficacy. In vivo experiment, 14-day-old chickens were injected respectively with sGPS(3), sGPS(5) and sGPS(6) when they were vaccinated with ND vaccine taking unmodified GPS as control. The results showed that three sGPSs could significantly promote lymphocyte proliferation, enhance serum antibody titer, IFN-gamma and IL-2 contents. These results indicated that selenylation modification could significantly enhance the immune-enhancing activity of GPS, sGPS(6) possessed the best efficacy and could be as a candidate drug of immunoenhancer. Its optimal modification conditions were 400 mg of sodium selenite for 500 mg of GPS, reaction temperature of 70 degrees C and reaction time of 6 h.
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