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Six Alkaloids Inhibit Secretion of IL-1 alpha, TXB2, ET-1 and E-selectin in LPS-induced Endothelial Cells

文献类型： 外文期刊

作者： Hu, Yi-Yi 1 ; He, Kong-Wang 1 ; Guo, Rong-li 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Vet Med, Nanjing 210014, Jiangsu, Peoples R China

关键词： IL-1 alpha;TXB2;ET-1;E-selectin;LPS;Alkaloid

期刊名称：IMMUNOLOGICAL INVESTIGATIONS （ 影响因子：3.657； 五年影响因子：3.279 ）

ISSN： 0882-0139

年卷期： 2012 年 41 卷 3 期

页码：

收录情况： SCI

摘要： The aim of the research was to investigate the antiendotoxin effects of Sinomenine, Fangchinoline, Stachydrine, Chuanxionggzine, Oxymartrine and Evodiamine. Endothelial cells were challenged with 1 mu g/mL LPS for 3 h then treated respectively with six alkaloids at three concentrations ( 1, 5 and 10 mu g/mL). The cells were incubated at 37 degrees C in a cell incubator for 21 h. The supernatants were collected and analyzed the levels of interleukin-1 alpha (IL-1 alpha), thromboxane B-2 (TXB2), endothelin-1 (ET-1) and E-selectin by ELISA kits. The results revealed that Sinomenine, Oxymartrine and Evodiamine inhibited the production of IL-1 alpha; Stachydrine, Chuanxionggzine and Evodiamine inhibited the secretion of TXB2; Sinomenine and Oxymartrine down-regulated ET-1 expression; Fangchinoline and Evodiamine decreased the level of E-selectin. All these changes were significant. Taken together, the data suggested that six alkaloids may effectively reduce inflammatory response via these cytokines.

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