文献类型： 外文期刊
作者： Zhang, Jun 1 ; Meng, Lin-Lin 1 ; Wei, Jing-Jing 2 ; Fan, Peng 1 ; Liu, Sha-Sha 1 ; Yuan, Wei-Yu 1 ; Zhao, You-Xing 3 ; Lu 1 ;
作者机构： 1.Hebei Univ, Coll Life Sci, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China
2.Hebei Univ, Coll Pharmaceut Sci, Key Lab Pharmaceut Qual Control Hebei Prov, Baoding 071002, Peoples R China
3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China
关键词： Isaria fumosorosea;PTP1B;pyrrolidinedione
期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）
ISSN： 1420-3049
年卷期： 2017 年 22 卷 12 期
页码：
收录情况： SCI
摘要： Protein tyrosine phosphatase 1B (PTP1B) is implicated as a negative regulator of insulin receptor (IR) signaling and a potential drug target for the treatment of type II diabetes and other associated metabolic syndromes. Thus, small molecule inhibitors of PTP1B can be considered as an attractive approach for the design of new therapeutic agents of type II diabetes and cancer diseases. In a continuing search for new PTP1B inhibitors, a new tetramic acid possessing a rare pyrrolidinedione skeleton named fumosorinone A (1), together with five known ones 2-6 were isolated from the entomogenous fungus Isaria fumosorosea. The structures of 2-6 were elucidated by extensive spectroscopic analysis. Fumosorinone A (1) and beauvericin (6) showed significant PTP1B inhibitory activity with IC50 value of 3.24 M and 0.59 M.
- 相关文献
作者其他论文 更多>>
-
Diverse ansamycin derivatives from the marine-derived Streptomyces sp. ZYX-F-97 and their antibacterial activities
作者：Yi, Ke-Xin;Hao, Yu-E;Xie, Qing-Yi;Ma, Qing-Yun;Yang, Li;Dai, Hao-Fu;Zhao, You-Xing;Xie, Qing-Yi;Ma, Qing-Yun;Yang, Li;Dai, Hao-Fu;Zhao, You-Xing
关键词：Marine-derived actinomycetes; Ansamycin derivatives; Antibacterial activity; Streptomyces sp.
-
Diaporchalasins A-E, New Cytochalasins from the Endophytic Fungus Diaporthe sp. BMX12 Isolated from Aquilaria sinensis
作者：Yang, Li;Wang, Qi;Ma, Qing-Yun;Xie, Qing-Yi;Gai, Cui-Juan;Dai, Hao-Fu;Zhao, You-Xing;Yang, Li;Wang, Qi;Ma, Qing-Yun;Xie, Qing-Yi;Gai, Cui-Juan;Dai, Hao-Fu;Zhao, You-Xing;Wu, You-Gen
关键词：Diaporthe sp.; Endophytic fungus; Cytochalasin; Cytotoxicity
-
Semisynthesis and antitumor activity of endertiin B and related triterpenoids from Ganoderma lucidum
作者：Liu, Yu;Wen, Hong-Kai;Xu, Rui-Xuan;Liu, Chang;Li, Xiao-Han;Luo, Dou-Qiang;Jia, Yan-Xing;Jia, Yan-Xing;Liu, Yu;Wen, Hong-Kai;Xu, Rui-Xuan;Liu, Chang;Li, Xiao-Han;Qin, Xiang-Dong;Luo, Dou-Qiang;Zhao, You-Xing
关键词：
-
Comparative transcriptomic analysis reveals the molecular mechanism underlying seedling heterosis and its relationship with hybrid contemporary seeds DNA methylation in soybean
作者：Ren, Xiaobo;Chen, Liangyu;Deng, Lin;Zhao, Qiuzhu;Li, Xueying;Cong, Weixuan;Zang, Zhenyuan;Zhao, Dingyi;Zhang, Miao;Yang, Songnan;Zhang, Jun;Chen, Liangyu;Yao, Dan;Zhang, Jun
关键词：soybean; seedling heterosis; RNA-Seq; DNA methylation; contemporary hybrid seed
-
Lanostane triterpenoids from the fruiting bodies of Ganoderma amboinense
作者：Yang, Li;Dong, Guan-Hai;Ma, Qing-Yun;Xie, Qing-Yi;Guo, Jiao-Cen;Dai, Hao-Fu;Zhao, You-Xing;Yang, Li;Dong, Guan-Hai;Ma, Qing-Yun;Xie, Qing-Yi;Guo, Jiao-Cen;Dai, Hao-Fu;Zhao, You-Xing;Wu, You-Gen;Lu, Jia-Ju
关键词：Ganoderma amboinense . lanostane triterpenoid; alpha-glucosidase inhibitory activity; Anti-inflammatory activity
-
A New Macrolide from the Strain Cordyceps spp. from Cell Fusion between Cordyceps militaris and Cordyceps cicadae
作者：Yang, Ning-Ning;Yang, Ning-Ning;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Yu, Zhi-Fang
关键词：Cordyceps spp.; cephalolidedifuran A; AChE inhibitory activity; antinematode activity
-
Anti-diabetic and anti-inflammatory indole diterpenes from the marine-derived fungus Penicillium sp. ZYX-Z-143
作者：Dai, Lu-Ting;Yang, Li;Guo, Jiao-Cen;Ma, Qing-Yun;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Dai, Lu-Ting;Yang, Li;Guo, Jiao-Cen;Ma, Qing-Yun;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Dai, Lu-Ting;Jiang, Li;Yu, Zhi-Fang
关键词：Indole diterpenoids; Penicillium sp.; PTP1B; Anti-inflammatory; alpha-glucosidase
