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A New Cytotoxic Pregnanone from Calotropis gigantea

文献类型: 外文期刊

作者: Wang, Zhu-Nian 1 ; Wang, Mao-Yuan 1 ; Mei, Wen-Li 2 ; Han, Zhuang 2 ; Dai, Hao-Fu 1 ;

作者机构: 1.Chinese Acad Trop Agr Sci, Inst Crops Genet Resources, Danzhou 571737, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

关键词: Calotropis gigantea L.;Calotropone;Cytotoxicity

期刊名称:MOLECULES ( 影响因子:4.411; 五年影响因子:4.587 )

ISSN: 1420-3049

年卷期: 2008 年 13 卷 12 期

页码:

收录情况: SCI

摘要: A new pregnanone, named calotropone (1), was isolated from the EtOH extract of the roots of Calotropis gigantea L. together with a known cardiac glycoside. The structures were elucidated by a study of their physical and spectral data. Compounds 1 and 2 displayed inhibitory effects towards chronic myelogenous leukemia K562 and human gastric cancer SGC-7901 cell lines.

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