文献类型： 外文期刊
作者： Wu, Rui 1 ; Sui, Zhiwei 2 ; Liu, Zewen 1 ; Liang, Wangwang 1 ; Yang, Keli 1 ; Xiong, Zhongliang 1 ; Xu, Diping 1 ;
作者机构： 1.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Wuhan 430064, Hubei, Peoples R China
2.Shijingshan Ctr Dis Control & Prevent Beijing Cit, Beijing 100043, Peoples R China
3.Hubei Key Lab Anim Embryo Engn & Mol Breeding, Wuhan 430064, Hubei, Peoples R China
关键词： Avian influenza virus;H9N2 subtype;Transmission;Contact spread;Droplet spread
期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）
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收录情况： SCI
摘要： Avian H9N2 influenza viruses have circulated widely in domestic poultry around the world, resulting in occasional transmission of virus from infected poultry to humans. However, it is unknown whether H9N2 influenza virus has acquired the ability to be transmitted from human to human. Here, we report that mouse-adapted H9N2 influenza viruses can replicate efficiently and are lethal for several strains of mice. To evaluate the transmissibility of mouse-adapted H9N2 influenza viruses, we carried out transmission studies in mice using both contact and respiratory droplet routes. Our results indicate that mouse-adapted H9N2 influenza viruses can replicate efficiently and be transmitted between mice. This suggests that once H9N2 influenza viruses adapt to new host, they should present potential public health risks, therefore, urgent attention should be paid to H9N2 influenza viruses.
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