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Discovery of a Dimeric Zinc Complex and Five Cyclopentenone Derivatives from the Sponge-Associated Fungus Aspergillus ochraceopetaliformis

文献类型： 外文期刊

作者： Guo, Cui 1 ; Wang, Pei 6 ; Pang, Xiaoyan 1 ; Lin, Xiuping 1 ; Liao, Shengrong 1 ; Yang, Bin 1 ; Zhou, Xuefeng 1 ; Wang, J 1 ;

作者机构： 1.Chinese Acad Sci, South China Sea Inst Oceanol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Peoples R China

2.Chinese Acad Sci, South China Sea Inst Oceanol, Guangdong Key Lab Marine Mat Med, Guangzhou 510301, Peoples R China

3.Chinese Acad Sci, RNAM Ctr Marine Microbiol, South China Sea Inst Oceanol, Guangzhou 510301, Peoples R China

4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China

5.Chinese Acad Sci, Innovat Acad South China Sea Ecol & Environm Engn, Guangzhou 510301, Peoples R China

6.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571101, Hainan, Peoples R China

7.Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China

期刊名称：ACS OMEGA （ 影响因子：2.87； 五年影响因子：2.905 ）

ISSN： 2470-1343

年卷期： 2021 年 6 卷 13 期

页码：

收录情况： SCI

摘要： In devotion to investigating structurally novel and biologically active marine natural products, a dimer of a zinc complex, dizinchydroxyneoaspergillin (1), aspernones A-E (2-6), five cyclopentenone derivatives together with known polyketides (7-10), and neoaspergillic acid analogues (11-14) were isolated from the sponge-associated fungus Aspergillus ochraceopetaliformis SCSIO 41018. Their structures were elucidated on the basis of spectroscopic analysis, electronic circular dichroism (ECD) analysis, and X-ray diffraction. Dizinchydroxyneoaspergillin (1) displayed significant bactericide effects toward methicillin-resistant Staphyloccocus aureus, Staphyloccocus aureus, Enterococcus faecalis, Acinetobacter baumannii, and Klebsiella pneumonia with MIC values of 0.45-7.8 mu g/mL and moderate in vitro cytotoxic activities against the K562, BEL-7402, and SGC-7901 cell lines with IC50 values of 12.88 +/- 0.14, 15.83 +/- 0.23, and 15.08 +/- 0.62 mu M, respectively. This is the first time to report the dimer of the zinc complex of hydroxyneoaspergillic acid conjunction at Zn-N-4 by a coordination bond. Additionally, compound 1 displayed significant antibacterial and cytotoxic activities, which would be a promising drug lead and could attract much attention from both chemists and pharmacists.

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