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Two new azaphilones from the marine-derived fungus Penicillium sclerotiorum E23Y-1A

文献类型： 外文期刊

作者： Wang, Sha 1 ; Zeng, Yanbo 2 ; Yin, Jianjun 1 ; Chang, Wenjun 2 ; Zhao, Xiaoliang 1 ; Mao, Yu 1 ;

作者机构： 1.Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730050, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Prov Key Lab Funct Components Res & Utiliz, Haikou 571101, Hainan, Peoples R China

关键词： Azaphilone; Marine-derived fungus; Penicillium sclerotiorum; Metabolite; Anti-inflammatory

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.873； 五年影响因子：1.875 ）

ISSN： 1874-3900

年卷期： 2022 年 47 卷

页码：

收录情况： SCI

摘要： Two new azaphilones, penicilazaphilones F (1) and G (2) together with two known analogs (3 and 4), were isolated from fermentation cultures of the marine-derived fungus Penicillium sclerotiorum E23Y-1A. Their structures were elucidated based on spectroscopic methods, including IR, MS, 1D and 2D NMR, as well as by comparison with published data. The absolute configuration of compound 1 was unambiguously determined using electronic circular dichroism (ECD) calculation. All isolated compounds were evaluated for their anti-inflammatory effects. Compounds 1-4 inhibited the lipopolysaccharide-induced production of nitric oxide (NO) in BV-2 cells, with IC50 values of 31.7 +/- 1.5, 34.5 +/- 1.4, 25.3 +/- 2.2, and 34.8 +/- 1.9 mu M, respectively. In contrast, these compounds showed no obvious cytotoxicity at a concentration of 50.0 mu M.

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