Two lanostane triterpenoids with alpha-glucosidase inhibitory activity from the fruiting bodies of Ganoderma weberianum
文献类型： 外文期刊
作者： Kong, De Xian 1 ; Ma, Qing Yun 2 ; Yang, Li 2 ; Xie, Qing Yi 2 ; Deng, Chun Ying 4 ; Dai, Hao Fu 2 ; Hua, Yan 1 ; Zhao, You Xing 2 ;
作者机构： 1.Southwest Forestry Univ, Key Lab Forest Resources Conservat & Utilizat Sou, Minist Educ, Kunming, Yunnan, Peoples R China
2.CATAS, Inst Trop Biosci & Biotechnol, Haikou Key Lab Res & Utilizat Trop Nat Prod, Haikou, Hainan, Peoples R China
3.CATAS, Hainan Inst Trop Agr Resources, Haikou, Hainan, Peoples R China
4.Guizhou Acad Sci, Guizhou Inst Biol, Guiyang, Peoples R China
关键词： Ganoderma weberianum; lanostane triterpenoids; alpha-glucosidase inhibitory activity
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.488； 五年影响因子：2.51 ）
ISSN： 1478-6419
年卷期：
页码：
收录情况： SCI
摘要： A new oxygenated lanostane-type triterpenoid, 20S,24S-epoxy-lanosta-7,9(11)-dien-3 beta,15 alpha,25R,26-tetraol (1), together with three known compounds (2-4) were isolated from the fruiting bodies of Ganoderma weberianum. Extensive NMR spectrometry and HRESIMS analysis, as well as NMR and ECD calculations elucidated the structure of the new compound. 27-nor-3 beta-hydroxylanosta-7,9(11),23E-trien-25-one (2) showed superior alpha-glucosidase inhibitory activity with IC50 value of 122.1 mu M to that of positive control acarbose (304.6 mu M). [GRAPHICS]
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