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Polymorphism in promoter of SIX4 gene shows association with its transcription and body measurement traits in Qinchuan cattle

文献类型： 外文期刊

作者： Wei, Dawei 1 ; Raza, Sayed Haidar Abbas 1 ; Zhang, Jiupan 3 ; Gui, Linsheng 1 ; Rahman, Siddiq Ur 4 ; Khan, Rajwali 1 ;

作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China

2.Northwest A&F Univ, Natl Beef Cattle Improvement Ctr, Yangling 712100, Peoples R China

3.Ningxia Acad Agr & Forestry Sci, Guyuan Branch, Guyuan 756000, Peoples R China

4.Northwest A&F Univ, Coll Life Sci, Yangling 712100, Peoples R China

5.Huazhaong Agr Univ, Coll Anim Sci & Technol, Wuhan 430070, Hubei, Peoples R China

6.Dalhousie Univ, Dept Anim Sci & Aquaculture, Halifax, NS, Canada

关键词： SIX4 gene promoter; SNPs; Body measurement traits; Qinchuan cattle

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

ISSN： 0378-1119

年卷期： 2018 年 656 卷

页码：

收录情况： SCI

摘要： The sine oculis homeobox homolog 4 (SIX4) gene belongs to the SIX gene family, which plays a critical role in muscle regeneration and early stages of ontogeny. This study aimed to detect promoter variations of bovine SIX4 genes in Qinchuan cattle, and to evaluate the effect of transcription regulations and body measurement traits. Quantitative real-time PCR (qPCR) results showed that the mRNA expression levels of SIX4 gene were found significantly highest in longissimus thoracic tissue and individual before attaining the stage of physiological maturity. Using sequencing technology on a total of 428 Qinchuan cattle, seven single nucleotide polymorphisms (SNPs) were identified in the promoter region of SIX4, and seven haplotypes representing 18 potential transcription factor compositions of polymorphic potential cis-acting elements. Association analysis indicated that the H-3-H-3 diplotype performed greater withers height, chest depth, chest circumference, back fat thickness and ultrasound loin muscle area (P < 0.05) than H-5-H-6, which were consistent with the promoter activity of Hap3 haplotype was higher than the Hap5 and Hap6 haplotype in vitro. These potential transcription factor information and combined genotypes H-3-H-3 of the SIX4 gene can be used as a molecular marker for selection of economic traits in Qinchuan cattle.

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