您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Host antiviral factors hijack furin to block SARS-CoV-2, ebola virus, and HIV-1 glycoproteins cleavage

文献类型： 外文期刊

作者： Yu, Changqing 1 ; Wang, Guosheng 3 ; Liu, Qiang 4 ; Zhai, Jingbo 5 ; Xue, Mengzhou 6 ; Li, Qiang 3 ; Xian, Yuanhua 1 ; Zheng, Chunfu 2 ;

作者机构： 1.Yibin Vocat & Tech Coll, Sch Adv Agr Sci, Yibin, Peoples R China

2.Guangdong Acad Agr Sci, Inst Anim Hlth, Sci Observat & Expt Stn Vet Drugs & Diagnost Tech, Key Lab Livestock Dis Prevent Guangdong Prov,Minis, Guangzhou, Peoples R China

3.Tongji Univ, Shanghai East Hosp, Sch Med, Dept Pulm & Crit Care Med, Shanghai, Peoples R China

4.Nanchong Vocat & Tech Coll, Nanchong Key Lab Dis Prevent Control & Detect Liv, Nanchong, Peoples R China

5.Inner Mongolia Minzu Univ, Med Coll, Key Lab Zoonose Prevent Control Univ Inner Mongol, Tongliao, Peoples R China

6.Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China

7.Univ Calgary, Dept Microbiol Immunol & Infect Dis, Calgary, AB, Canada

关键词： Antiviral factors; furin; viral glycoprotein; cleavage; SARS-CoV-2

期刊名称：EMERGING MICROBES & INFECTIONS （ 影响因子：13.2； 五年影响因子：9.9 ）

ISSN：

年卷期： 2023 年 12 卷 1 期

页码：

收录情况： SCI

摘要： Viral envelope glycoproteins are crucial for viral infections. In the process of enveloped viruses budding and release from the producer cells, viral envelope glycoproteins are presented on the viral membrane surface as spikes, promoting the virus's next-round infection of target cells. However, the host cells evolve counteracting mechanisms in the long-term virus-host co-evolutionary processes. For instance, the host cell antiviral factors could potently suppress viral replication by targeting their envelope glycoproteins through multiple channels, including their intracellular synthesis, glycosylation modification, assembly into virions, and binding to target cell receptors. Recently, a group of studies discovered that some host antiviral proteins specifically recognized host proprotein convertase (PC) furin and blocked its cleavage of viral envelope glycoproteins, thus impairing viral infectivity. Here, in this review, we briefly summarize several such host antiviral factors and analyze their roles in reducing furin cleavage of viral envelope glycoproteins, aiming at providing insights for future antiviral studies.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台