文献类型: 外文期刊
作者: Liao, Ge 2 ; Mei, Wen-Li 1 ; Dong, Wen-hua 1 ; Li, Wei 1 ; Wang, Pei 1 ; Kong, Fan-Dong 1 ; Gai, Cui-Juan 1 ; Song, Xi-Qi 1 ;
作者机构: 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Engn Res Ctr Agarwood, Haikou 571101, Hainan, Peoples R China
2.Hainan Univ, Coll Hort & Landscape Architecture, 58 Peoples Ave, Haikou 570228, Hainan, Peoples R China
3.Hainan Univ, Coll Hort
关键词: Aquilaria sinensis;Agarwood;2-(2-Phenylethyl)chromone;Biological activity
期刊名称:FITOTERAPIA ( 影响因子:2.882; 五年影响因子:3.202 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Seven new 2-(2-phenylethyl)chromone derivatives (1-7) including a chlorinated one (4), together with eight known ones (8-15), were isolated from the EtOAc extract of artificial agarwood originating from Aquilaria sinensis (Lour.) Gilg. All structures including the absolute configurations were unambiguously elucidated by spectroscopic (NMR, UV, IR, MS) methods, Mosher's method, and comparison with reported data in the literatures. Among those, compounds 8, 12, and' 14 exhibited significant inhibition against a-glucosidase in vitro with IC50 values of 0.15, 0.05, and 0.09 mM, respectively (with acarbose as the positive control; IC50: 0.98 mM). In addition, compounds 3, 9, 11, and 14 showed weak inhibitory activity against AChE; and compounds 12 and 13 displayed weak cytotoxicity against human gastric cell line (SGC-7901) among three types of tested human cancer cell lines (BEL-7402, K562, and SGC-7901). (C) 2016 Elsevier B.V. All rights reserved.
- 相关文献
作者其他论文 更多>>
-
Leveraging a phased pangenome for haplotype design of hybrid potato
作者:Cheng, Lin;Wang, Nan;Bao, Zhigui;Yang, Yuting;Wang, Pei;Zhang, Zhiyang;Tang, Die;Zhang, Pingxian;Wu, Yaoyao;Zhou, Yao;Zheng, Yi;Hu, Yong;Lian, Qun;Ma, Zhaoxu;Zhang, Chunzhi;Zhou, Yongfeng;Huang, Sanwen;Cheng, Lin;Lassois, Ludivine;Wang, Nan;Zhou, Yongfeng;Huang, Sanwen;Bao, Zhigui;Zhou, Qian;Guarracino, Andrea;Garrison, Erik;Tang, Die;Wu, Yaoyao;Zhou, Yao;Lucas, William J.;Stein, Nils;Stein, Nils;Staedler, Thomas;Staedler, Thomas
关键词:
-
New Isocoumarins from an Endophytic Fungal Strain Diaporthe arengae M2 and their Antibacterial Activities
作者:Liu, De-Sui;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Liu, De-Sui;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Dai, Hao-Fu;Zhao, You-Xing;Liu, De-Sui;Zhang, Jun-Feng;Wu, You-Gen
关键词:Endophytic fungi;
Diaporthe sp.; Isocoumarin derivatives; Antibacterial activity -
2-(2-Phenylethyl)chromone-Sesquiterpene Hybrids from Agarwood of Aquilaria sinensis: Characterization and Biological Activity Evaluation
作者:Xu, Guan-Hua;Liu, Shou-Bai;Xu, Guan-Hua;Wang, Ya-Li;Wang, Hao;Chen, Hui-Qin;Dong, Wen-Hua;Huang, Sheng-Zhuo;Cai, Cai-Hong;Yuan, Jing-Zhe;Mei, Wen-Li;Dai, Hao-Fu
关键词:Hainan agarwood; 2-(2-phenylethyl)chromone-sesquiterpene hybrids; structure elucidation; anti-inflammatory activity; neuroprotective activity; cytotoxic activity
-
Three new dimeric 2-(2-phenethyl)chromones from the agarwood of Aquilaria malaccensis
作者:Yan, Xian-Yun;Liang, Lin-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu;Yan, Xian-Yun;Li, Wei;Wang, Hao;Dong, Wen-Hua;Zeng, Jun;Wu, Fei;Mei, Wen-Li;Dai, Hao-Fu
关键词:Agarwood; Aquilaria malaccensis; 2-(2-phenethyl)chromone dimers; Anti-inflammatory activity
-
Nauclofficines A and B, two novel monoterpenoid indole alkaloids from the Li folk herb Nauclea officinalis with anti-allergic inflammatory effects on RBL-2H3 cells
作者:Li, Yan-li;Wang, Ting;Wang, Hao;Wang, Qi;Cai, Cai-Hong;Mei, Wen-Li;Dai, Hao-Fu;Huang, Sheng-Zhuo;Dai, Hao-Fu;Huang, Sheng-Zhuo;Li, Yan-li;Xu, Feng-Qing;Wang, Ting;Zhu, Guo-Peng
关键词:Nauclea officinalis; Monoterpenoid indole alkaloid; Li folk medicine; Anti-inflammatory activity; Nauclofficine
-
Two unprecedented 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones with anti-Helicobacter pylori activity from agarwood of Aquilaria sinensis 'Reke 1'
作者:Qin, Ke-Xin;Jian, Jie;Qin, Ke-Xin;Wang, Hao;Yang, Li;Wei, Yan-Mei;Cai, Cai-Hong;Chen, Hui-Qin;Dong, Wen-Hua;Li, Wei;Yan, Xian-Yun;Zeng, Jun;Mei, Wen-Li;Dai, Haofu;Qin, Ke-Xin;Wang, Hao;Yang, Li;Wei, Yan-Mei;Cai, Cai-Hong;Chen, Hui-Qin;Dong, Wen-Hua;Li, Wei;Yan, Xian-Yun;Zeng, Jun;Mei, Wen-Li;Dai, Haofu
关键词:Agarwood; Aquilaria sinensis 'Reke 1 '; 2-(2-Phenylethyl)chromone; Anti -Helicobacter pylori activity
-
Chemical composition of the endogenous fungus Fusarium sp. L-3 derived from Chinese Qinan agarwood
作者:Han, Ming-Li;Xiao, Na;Han, Ming-Li;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Guo, Jiao-Cen;Dai, Hao-Fu;Zhao, You-Xing;Han, Ming-Li;Ma, Qing-Yun;Yang, Li;Xie, Qing-Yi;Guo, Jiao-Cen;Dai, Hao-Fu;Zhao, You-Xing
关键词:Fusarium sp; Chinese agarwood 'Qi-Nan'; secondary metabolites; anti-inflammatory; alpha-glucosidase inhibition



