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2-(2-Phenylethyl)chromone derivatives in artificial agarwood from Aquilaria sinensis

文献类型: 外文期刊

作者: Liao, Ge 2 ; Mei, Wen-Li 1 ; Dong, Wen-hua 1 ; Li, Wei 1 ; Wang, Pei 1 ; Kong, Fan-Dong 1 ; Gai, Cui-Juan 1 ; Song, Xi-Qi 1 ;

作者机构: 1.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Engn Res Ctr Agarwood, Haikou 571101, Hainan, Peoples R China

2.Hainan Univ, Coll Hort & Landscape Architecture, 58 Peoples Ave, Haikou 570228, Hainan, Peoples R China

3.Hainan Univ, Coll Hort

关键词: Aquilaria sinensis;Agarwood;2-(2-Phenylethyl)chromone;Biological activity

期刊名称:FITOTERAPIA ( 影响因子:2.882; 五年影响因子:3.202 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Seven new 2-(2-phenylethyl)chromone derivatives (1-7) including a chlorinated one (4), together with eight known ones (8-15), were isolated from the EtOAc extract of artificial agarwood originating from Aquilaria sinensis (Lour.) Gilg. All structures including the absolute configurations were unambiguously elucidated by spectroscopic (NMR, UV, IR, MS) methods, Mosher's method, and comparison with reported data in the literatures. Among those, compounds 8, 12, and' 14 exhibited significant inhibition against a-glucosidase in vitro with IC50 values of 0.15, 0.05, and 0.09 mM, respectively (with acarbose as the positive control; IC50: 0.98 mM). In addition, compounds 3, 9, 11, and 14 showed weak inhibitory activity against AChE; and compounds 12 and 13 displayed weak cytotoxicity against human gastric cell line (SGC-7901) among three types of tested human cancer cell lines (BEL-7402, K562, and SGC-7901). (C) 2016 Elsevier B.V. All rights reserved.

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