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MsmK, an ATPase, Contributes to Utilization of Multiple Carbohydrates and Host Colonization of Streptococcus suis

文献类型： 外文期刊

作者： Tan, Mei-Fang 1 ; Gao, Ting 1 ; Liu, Wan-Quan 1 ; Zhang, Chun-Yan 1 ; Yang, Xi 1 ; Zhu, Jia-Wen 1 ; Teng, Mu-Ye 1 ; Li, L 1 ;

作者机构： 1.Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China

2.Hubei Acad Agr Sci, Inst Anim Husb & Vet, Wuhan 430064, Peoples R China

3.Cooperat Innovat Ctr Sustainable Pig Prod, Wuhan 430070, Peoples R China

4.Cooperat Innovat Ctr Sustainable Pig Pro

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2015 年 10 卷 7 期

页码：

收录情况： SCI

摘要： Acquisition and metabolism of carbohydrates are essential for host colonization and pathogenesis of bacterial pathogens. Different bacteria can uptake different lines of carbohydrates via ABC transporters, in which ATPase subunits energize the transport though ATP hydrolysis. Some ABC transporters possess their own ATPases, while some share a common ATPase. Here we identified MsmK, an ATPase from Streptococcus suis, an emerging zoonotic bacterium causing dead infections in pigs and humans. Genetic and biochemistry studies revealed that the MsmK was responsible for the utilization of raffinose, melibiose, maltotetraose, glycogen and maltotriose. In infected mice, the msmK-deletion mutant showed significant defects of survival and colonization when compared with its parental and complementary strains. Taken together, MsmK is an ATPase that contributes to multiple carbohydrates utilization and host colonization of S. suis. This study gives new insight into our understanding of the carbohydrates utilization and its relationship to the pathogenesis of this zoonotic pathogen.

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