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Toxicarioside N induces apoptosis in human gastric cancer SGC-7901 cell by activating the p38MAPK pathway

文献类型： 外文期刊

作者： Zhao, Huan-Ge 1 ; Zhou, Song-Lin 1 ; Lin, Ying-Ying 1 ; Dai, Hao-Fu 3 ; Huang, Feng-Ying 1 ;

作者机构： 1.Hainan Med Coll, Key Lab Translat Med Trop Dis, Minist Educ, Haikou 571199, Hainan, Peoples R China

2.Hainan Med Coll, Hainan Prov Key Lab Trop Med, Haikou 571199, Hainan, Peoples R China

3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Haikou 571199, Hainan, Peoples R China

关键词： Toxicarioside N;SGC-7901 cells;Apoptosis;p38MAPK

期刊名称：ARCHIVES OF PHARMACAL RESEARCH （ 影响因子：4.946； 五年影响因子：3.483 ）

ISSN： 0253-6269

年卷期： 2018 年 41 卷 1 期

页码：

收录情况： SCI

摘要： Natural plant compounds with potent proliferation inhibition and apoptosis induction properties have been screened as novel anticancer drugs. Toxicarioside N (Tox N) was isolated from the seeds of the tropical plant Antiaris toxicaria in Hainan province, China. To our knowledge, the effects that Tox N has on the apoptosis of SGC-7901 cells and its potential mechanism have never been investigated. In this study, we detected the anticancer activities of Tox N and explored the potential mechanism in the human gastrointestinal cancer cell line SGC-7901. Here, we found that Tox N inhibited SGC-7901 cell growth in a dose- and time-dependent manner and induced apoptosis in cells based on cell morphology and flow cytometry analyses. Additionally, the SGC-7901 cell treated with Tox N up-regulated the expression level of cleaved caspase-3/9 and PARP, increased the Bax/Bcl-2 ratio, and led to the release of cytochrome c into the cytoplasm. In addition, Tox N treatment led to the phosphorylation of p38MAPK. SB203580, a p38MAPK inhibitor, partially attenuated Tox N induced apoptosis by preventing the activation of caspase-3/9 and PARP. Our results indicated for the first time that Tox N can induce SGC-7901 cells apoptosis by activating the p38MAPK pathway.

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