文献类型： 外文期刊
作者： Yan, Jian 1 ; Sun, Li-Rong 2 ; Zhou, Zhong-Yu 1 ; Chen, Yu-Chan 3 ; Zhang, Wei-Min 3 ; Dai, Hao-Fu 4 ; Tan, Jian-Wen 1 ;
作者机构： 1.Chinese Acad Sci, S China Bot Garden, Key Lab Plant Resources Conservat & Sustainable U, Guangzhou 510650, Guangdong, Peoples R China
2.So Med Univ, Sch Basic Med Sci, Guangzhou 510515, Guangdong, Peoples R China
3.Guangdong Inst Microbiol, Guangdong Prov Key Lab Microbial Culture Collect, Guangdong Open Lab Appl Microbiol, Guangzhou 510070, Guangdong, Peoples R China
4.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, State Key Lab Trop Crops Biotechnol, Haikou 571101, Peoples R China
关键词： Portulaca oleracea;Portulacaceae;Homoisoflavonoid;Portulacanone;Cytotoxic activity
期刊名称：PHYTOCHEMISTRY （ 影响因子：4.072； 五年影响因子：4.132 ）
ISSN： 0031-9422
年卷期： 2012 年 80 卷
页码：
收录情况： SCI
摘要： Four homoisoflavonoids named portulacanones A-D, identified as 2'-hydroxy-5,7-dimethoxy-3-benzyl-chroman-4-one, 2'-hydroxy-5,6,7-trimethoxy-3-benzyl-chroman-4-one, 5,2'-dihydroxy-6,7-dimethoxy-3-benzyl-chroman-4-one, and 5,2'-dihydroxy-7-methoxy-3-benzylidene-chroman-4-one, were isolated from aerial parts of the plant Portulaca oleracea along with nine other known metabolites. Their structures were established on the basis of extensive spectroscopic analyses. Portulacanones A-D is the first group of homoisoflavonoids so far reported from the family Portulacaceae. They represent a rare subclass of homoisoflavonoids in nature with a structural feature of a single hydroxyl group substituted at C-2' rather than at C-4' in ring B of the skeleton. Three homoisoflavonoids and the known compound 2,2'-dihydroxy-4',6'-dimethoxychalcone selectively showed in vitro cytotoxic activities towards four human cancer cell lines. Especially 2,2'-dihydroxy-4',6'-dimethoxychalcone showed cytotoxic activity against cell line SGC-7901 with an IC50 value of 1.6 mu g/ml, which was more potent than the reference compound mitomycin C (IC50 13.0 mu g/ml). (C) 2012 Elsevier Ltd. All rights reserved.
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