您好,欢迎访问中国热带农业科学院 机构知识库!

Ochracenes A-I, Humulane-Derived Sesquiterpenoids from the Antarctic Fungus Aspergillus ochraceopetaliformis

文献类型: 外文期刊

作者: Wang, Junfeng 1 ; He, Weijun 1 ; Kong, Fandong 3 ; Tian, Xinpeng 1 ; Wang, Pei 4 ; Zhou, Xiaojiang 2 ; Liu, Yonghong 1 ;

作者机构: 1.Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Guangdong, Peoples R China

2.Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China

3.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Key Lab Biol & Genet Resources Trop Crops, Minist Agr, Haikou 571101, Peoples R China

4.Chinese Acad Trop Agr Sci, Inst Trop

期刊名称:JOURNAL OF NATURAL PRODUCTS ( 影响因子:4.05; 五年影响因子:4.603 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Nine new humulane-derived sesquiterpenoids, ochracenes A-I (1-9), were isolated from the Antarctic fungus Aspergillus ochraceopetaliformis SCSIO 05702. Their structures including absolute configurations were elucidated on the basis of spectroscopic analysis, Mosher's method, and electronic circular dichroism analysis. Compared with previous humulane-type sesquiterpenoids, ochracenes A-I (1-9) featured novel carbon skeletons with corresponding methyl migration, ring cleavage, and carbon loss. Two unprecedented 8,9-secocyclic sesquiterpenoids (2 and 3) exhibited inhibitory effects on lipopolysaccharide-induced NO release in RAW 264.7 mouse macrophage cell lines with IC50 values of 14.6 +/- 0.5 and 18.3 +/- 1.7 mu M, respectively.

  • 相关文献
作者其他论文 更多>>